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PhD Scholarships: Bio-Sciences

PhD Scholarships Monday 8 June 2015

Liverpool Hope has launched a series of PhD Scholarships and welcomes applications from outstanding individuals of a high calibre to pursue PhD research at Liverpool Hope University in selected areas. We are seeking confident, innovative postgraduates with a record of achievement to undertake a broad range of thematic and inter-disciplinary projects. This call is open to both UK/EU and international applicants.

You can find full details about the Scholarships on the PhD Scholarships webpage or you can also contact Research Officer Mr Chris Lowry quoting '2015 Vice-Chancellor's PhD Scholarships' for more information, by emailing researchdegrees@hope.ac.uk

The Scholarships available will be selected from a range of specific project. Over the coming weeks, www.hope.ac.uk will profile the details of these areas of research. 

 

Bio-Sciences

Physiological determinants of critical power and exercise tolerance in health and disease

Principal Investigator: Dr Simon Marwood marwoos@hope.ac.uk

Poor exercise tolerance can result in the inability to undertake apparently everyday activities, such as walking the dog or going to the shops. The capacity to tolerate exercise is therefore an important contributor to the quality of life in a wide range of chronic diseases. Furthermore, exercise tolerance can predict disease severity, risk of death from disease and post-surgical complications in a wide range of clinical conditions.

Underpinning the capacity to tolerate a given exercise-related task is a fixed maximal intensity of exercise that can be sustained for prolonged periods of time without fatigue. An understanding of the physiology underpinning this maximal, sustainable intensity is therefore fundamental to our understanding of the inter-relationship between quality of life, clinical risk and exercise interventions.

It is known that the maximal sustainable exercise intensity is related to the rate at which oxygen consumption increases in response to exercise. However whether more rapid increases in oxygen consumption causes, or is simply related to, the maximal sustainable intensity is not known. The purpose of this project is therefore to examine, in health and disease, the relationship between the rate of increase of oxygen uptake at the onset of exercise and the maximal sustainable exercise intensity.

 

Targeting parasite hibernation: post-genomics investigation of the metabolism of young malaria parasites

Principal Investigator: Dr J Enrique Salcedo-Sora salcede@hope.ac.uk

Malaria is currently treated worldwide with artemisinins. There are recent indications of resistance to these drugs by the parasite going into “hibernation”. This PhD project will be part of the investigation of the metabolism of this dormant state of the malaria parasite. The project is a multi-disciplinary and multi-centre work.

Three different departments from three different institutions are involved: Liverpool Hope University, Liverpool School of Tropical Medicine and the Department of Chemical Engineering of the University of Chester.

New insights into the biology of metabolism of dormancy in malaria is of the highest priority at present. The candidate will undertaking studies using different post-genomics technologies along experimentation in cell biology and biochemistry of the malaria parasite. The project is expect to impact ongoing efforts into the control, management and target discovery for the imminent drug resistance to the current and most used antimalarials.

 

Functional Genomic Analysis of HLA Region Disease Associations

Principal Investigator: Professor Mehmet T Dorak dorakm@hope.ac.uk

Genetic predisposition to disease is a very popular subject thanks to the completion of many genome-wide association studies to identify markers for disease risk. While it is straightforward to identify markers for risk, it has been a slow progress to convert these findings to clinically useful information. One region of the human genome, called the HLA complex, is particularly difficult to work with due to its complex structure. This project is designed to systematically examine the disease markers mapping to the HLA complex, explore the functional changes they cause in the genome and find out how they cause disease. This information is needed to devise preventive measures and possibly new treatments. The aims of the project will be achieved by a combination of bioinformatics and experimental approaches, in other words, both dry and wet laboratory work will be carried out. Professor Dorak has extensive experience in genetic association studies, molecular genetics and the HLA complex. The work will take place in the brand new Health Sciences Laboratory which will include dedicated bioinformatics and molecular genetics and cell biology laboratories.


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